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Related Experiment Video

Updated: Jan 20, 2026

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Granulomatous slack skin: case report with electron microscopic features.

Bo Wang1, Jie Zheng, Hong-Wei Wang

  • 1Department of Dermatology, University of Michigan, Ann Arbor, MI Department of Dermatology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai. makiwang@umich.edu.

Dermatology Online Journal
|August 27, 2019
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Summary

Granulomatous slack skin (GSS), a rare mycosis fungoides subtype, presents as slow-growing skin plaques. Electron microscopy reveals atypical T cells, lymphophagocytosis, and elastophagocytosis as key diagnostic features.

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Area of Science:

  • Dermatopathology
  • Oncology
  • Immunology

Background:

  • Granulomatous slack skin (GSS) is an uncommon variant of mycosis fungoides.
  • It typically manifests as slowly progressing, erythematous, and lax skin plaques, often affecting skin folds.

Observation:

  • This report details a specific case of GSS.
  • Electron microscopy was utilized for detailed examination of the affected tissue.

Findings:

  • Key ultrastructural findings in GSS include atypical T cells.
  • These cells exhibit characteristic convoluted and cerebriform nuclei.
  • The presence of lymphophagocytosis and elastophagocytosis are crucial diagnostic markers.

Implications:

  • Electron microscopy provides essential diagnostic criteria for GSS.
  • Understanding these cellular features aids in differentiating GSS from other cutaneous lymphomas.
  • This case contributes to the literature on rare mycosis fungoides subtypes.