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Targeting Metabolic Reprogramming in Acute Myeloid Leukemia.
Isabel Castro1,2, Belém Sampaio-Marques1,2, Paula Ludovico3,4
1Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, 4710-057 Braga, Portugal.
Cells
|August 28, 2019
Summary
Cancer cells reprogram metabolism for growth and survival. Targeting these metabolic changes in acute myeloid leukemia (AML) offers promising therapeutic strategies currently under investigation.
Area of Science:
- Oncology
- Cancer Metabolism
- Biochemistry
Background:
- Cancer cells exhibit metabolic reprogramming to support proliferation, expansion, and survival.
- Metabolic alterations meet increased bioenergetic, biosynthetic, and redox demands of tumor cells.
- Metabolites also play crucial roles in signaling pathways that drive tumor growth and progression.
Purpose of the Study:
- To review the metabolic complexity of acute myeloid leukemia (AML).
- To discuss the efficacy of therapies targeting cellular metabolism in AML.
- To explore the therapeutic window offered by targeting AML cell metabolic requirements.
Main Methods:
- Literature review of cancer metabolism.
- Analysis of metabolic alterations in acute myeloid leukemia.
- Review of preclinical and clinical trial data for metabolic therapies in AML.
Main Results:
- Metabolic reprogramming is essential for cancer cell functions.
- Targeting cancer metabolism has shown efficacy in various cancers, including AML.
- Metabolic pathways in AML present viable therapeutic targets.
Conclusions:
- Targeting the unique metabolic dependencies of AML cells offers a promising therapeutic avenue.
- Exploiting metabolic vulnerabilities can lead to effective treatment strategies for AML.
- Further exploration of metabolic therapies is warranted for acute myeloid leukemia.
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