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Modeling The Lifecycle Of Ebola Virus Under Biosafety Level 2 Conditions With Virus-like Particles Containing Tetracistronic Minigenomes
Published on: September 27, 2014
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Pulmonary Involvement during the Ebola Virus Disease.
Eleonora Lalle1, Mirella Biava1, Emanuele Nicastri1
1National Institute for Infectious Diseases 'Lazzaro Spallanzani' IRCCS, 00149 Rome, Italy.
Viruses
|August 28, 2019
Summary
Ebola virus disease (EVD) can affect the lungs, as seen during the 2013-2016 outbreak. This review focuses on new findings regarding lung pathology and potential aerosol transmission of Ebola virus (EBOV).
Area of Science:
- Virology
- Public Health
- Pathology
Background:
- Filoviruses, particularly Ebola virus (EBOV), pose a significant global health threat.
- The 2013-2016 Western Africa Ebola Virus Disease (EVD) outbreak was the largest recorded, highlighting the virus's impact.
- EVD affects multiple organs, including the liver, kidney, and lungs, but pulmonary pathogenesis remains poorly understood.
Purpose of the Study:
- To review and highlight the pulmonary involvement in Ebola Virus Disease (EVD).
- To focus on emerging data concerning lung pathogenesis during the 2013-2016 EVD outbreak.
- To address the controversial issue of aerosol transmission of EBOV.
Main Methods:
- This study is a review of existing literature and data.
- Focuses on findings from the 2013-2016 Western Africa EVD outbreak.
- Analysis of reported cases and scientific observations regarding lung pathology.
Main Results:
- Ebola virus (EBOV) was detected in the lungs of patients during the outbreak.
- Evidence suggests a significant role for the lungs in EVD pathogenesis.
- New data provides insights into pulmonary manifestations and potential transmission routes.
Conclusions:
- Pulmonary involvement is a critical aspect of Ebola Virus Disease (EVD).
- Further research is needed to fully understand EVD lung pathogenesis and aerosol transmission.
- The findings underscore the importance of considering respiratory involvement in EVD management and control.
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