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Updated: Jan 20, 2026

Identification and Dissection of Diverse Mouse Adipose Depots
Published on: July 11, 2019
The Diverse Contributions of Fucose Linkages in Cancer
Tyler S Keeley1,2,3, Shengyu Yang4, Eric Lau5
1Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, PA 17033, USA.
Abstract:
Fucosylation is a post-translational modification of glycans, proteins, and lipids that is responsible for many biological processes. Fucose conjugation via α(1,2), α(1,3), α(1,4), α(1,6), and O'- linkages to glycans, and variations in fucosylation linkages, has important implications for cancer biology. This review focuses on the roles that fucosylation plays in cancer, specifically through modulation of cell surface proteins and signaling pathways. How L-fucose and serum fucosylation patterns might be used for future clinical diagnostic, prognostic, and therapeutic approaches will be discussed.
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