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Estimation of Nephron Number in Whole Kidney using the Acid Maceration Method
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ERK1,2 Signalling Pathway along the Nephron and Its Role in Acid-base and Electrolytes Balance

Giovanna Capolongo1, Yoko Suzumoto2, Mariavittoria D'Acierno2

  • 1Department of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.

International Journal of Molecular Sciences
|August 28, 2019
PubMed

Insights

Extracellular signal-regulated protein kinases (ERK 1,2) are crucial for kidney development and function. This study reveals ERK1,2 signaling

Area of Science:

  • Molecular Biology
  • Renal Physiology
  • Cell Signaling

Background:

  • Mitogen-activated protein kinases (MAPKs) regulate diverse cellular processes.
  • MAPK activity is present in normal kidneys and dysregulated in renal diseases.
  • Extracellular signal-regulated protein kinases (ERK 1,2) is a key MAPK pathway.

Purpose of the Study:

  • To investigate the role of ERK1,2 signaling in mature kidney function.
  • To elucidate the contribution of ERK1,2 to ion transport and homeostasis along the nephron.

Main Methods:

  • Analysis of ERK1,2 signaling pathways in mature kidney tissues.
  • Investigation of ERK1,2 involvement in nephron cellular functions.
  • Assessment of ERK1,2 regulation of ion channels and transporters.

Main Results:

  • ERK1,2 signaling mediates critical cellular functions in the mature kidney.
  • The pathway plays a role in regulating ion channels and transporters.
  • ERK1,2 signaling contributes to maintaining acid-base and electrolyte homeostasis.

Conclusions:

  • ERK1,2 signaling is essential for both kidney development and mature kidney function.
  • Understanding ERK1,2's role in ion transport is vital for renal homeostasis.
Keywords:
ERK1,2MAPKacid-basecell signalingelectrolytes

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