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Optimizing the Limit of Detection of Waveguide-Based Interferometric Biosensor Devices.

Jonas Leuermann1,2, Adrián Fernández-Gavela3, Antonia Torres-Cubillo4

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Reducing noise in waveguide-based photonic sensors significantly enhances their detection limits. This study demonstrates a low limit of detection (∼ 10-8 RIU) using silicon nitride sensors, improving low-cost diagnostic devices.

Keywords:
biosensorscoherent detectioninterferometerlimit of detectionsilicon photonics

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Area of Science:

  • Photonics
  • Sensor Technology
  • Biomedical Engineering

Background:

  • Waveguide-based photonic sensors offer high sensitivity, compact size, and label-free operation.
  • Interferometric configurations allow simple, fixed-wavelength readout, ideal for low-cost diagnostics.
  • Sensor performance is limited by response to refractive index changes and readout noise.

Purpose of the Study:

  • To investigate the impact of noise reduction on the limit of detection (LOD) in waveguide photonic sensors.
  • To demonstrate significant LOD enhancement through systematic noise optimization.
  • To achieve a low LOD for practical diagnostic and monitoring applications.

Main Methods:

  • Utilized silicon nitride waveguide sensors operating at telecom wavelengths.
  • Focused on systematic noise reduction strategies in the readout system.
  • Characterized sensor performance and quantified the limit of detection.

Main Results:

  • Achieved order-of-magnitude enhancements in the limit of detection.
  • Demonstrated a limit of detection of approximately 10^-8 RIU (Refractive Index Unit).
  • Showcased the effectiveness of noise reduction in improving sensor sensitivity.

Conclusions:

  • Systematic noise reduction is crucial for optimizing LOD in photonic sensors.
  • The developed sensor technology shows promise for advanced, low-cost diagnostic and monitoring devices.
  • Further research into noise optimization can unlock the full potential of waveguide-based photonic sensors.