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Probiotics for Parkinson's Disease.

Parisa Gazerani1

  • 1Biomedicine: Department of Health Science and Technology, Faculty of Medicine, Aalborg University，Frederik Bajers Vej 3B, 9220 Aalborg East, Denmark. gazerani@hst.aau.dk.

International Journal of Molecular Sciences
|August 28, 2019
PubMed
Summary

This review explores probiotics for Parkinson's disease (PD), a complex neurological disorder. Research indicates a gut-brain axis link, suggesting probiotics may offer new therapeutic avenues for PD management.

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Area of Science:

  • Neuroscience
  • Microbiology
  • Gastroenterology

Background:

  • Parkinson's disease (PD) is a neurodegenerative disorder primarily affecting motor function due to dopaminergic neuron loss.
  • PD complexity involves genetic and environmental factors, leading to motor and non-motor symptoms, necessitating early diagnosis.
  • Emerging research highlights the gut-brain axis and its potential role in PD pathogenesis.

Purpose of the Study:

  • To review the current status of probiotic use in managing Parkinson's disease.
  • To examine the influence of probiotics on the gut microbiota and its impact on the gut-brain axis in PD.
  • To identify limitations and future research directions for probiotic-based PD therapies.

Main Methods:

  • Literature review of studies investigating probiotics for Parkinson's disease.
Keywords:
Parkinson’s diseasedysbiosisgastrointestinalgutmicrobiotaprebioticsprobioticssynbiotics

Related Experiment Videos

  • Analysis of evidence on the gut-brain axis and microbiota alterations in PD.
  • Synthesis of findings on probiotic efficacy, safety, and mechanisms of action.

    • Main Results:

    • Alterations in gut microbiota are linked to Parkinson's disease.
    • Probiotics, prebiotics, and synbiotics are being investigated for their potential to modulate the gut microbiota and influence the gut-brain axis.
    • Preliminary evidence suggests probiotics may impact enteric nervous system and central nervous system functions relevant to PD.

    Conclusions:

    • The gut-brain axis presents a promising target for novel Parkinson's disease interventions.
    • Probiotics warrant further investigation as a potential therapeutic strategy for Parkinson's disease.
    • Future research should focus on well-designed clinical trials to establish the efficacy and optimal use of probiotics in PD management.