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Related Concept Videos

Additional Routes of Drug Administration01:18

Additional Routes of Drug Administration

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Choosing the appropriate route of drug administration is significantly influenced by two key factors: the therapeutic objectives and the inherent properties of the drug being used.
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
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Routes of Drug Administration: Enteral01:18

Routes of Drug Administration: Enteral

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Medications can be administered through the enteral route using liquids, capsules, or tablets.
Enteral administration involves drug administration via the mouth in two ways: orally or sublingually.
Unlike sublingually drugs, drugs that are taken orally pass through the gastrointestinal (GI) tract and get metabolized by the liver. Once metabolized, the drug is absorbed into the systemic circulation, reaching different body parts via the bloodstream. However, while passing through the stomach,...
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Routes of Drug Administration: Parenteral01:25

Routes of Drug Administration: Parenteral

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The administration of drugs via parenteral routes allows for direct drug introduction into the systemic circulation, resulting in high bioavailability because the medication bypasses the harsh conditions of the gastrointestinal tract and hepatic metabolism.
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...
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Routes of Drug Administration: Overview01:22

Routes of Drug Administration: Overview

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Drug administration involves delivering drugs to the body through various routes, such as enteral, parenteral, and topical.
Enteral administration refers to drugs absorbed through the gastrointestinal tract. They can be swallowed (perorally), placed under the tongue (sublingually), or on the inner lining of the cheeks (buccally). Perorally administered drugs take time to be absorbed and have a slower onset of action. The rectal route is another form of enteral administration, which allows for...
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Drugs Affecting Neurotransmitter Synthesis01:29

Drugs Affecting Neurotransmitter Synthesis

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Drugs affecting neurotransmitter synthesis can impact the adrenergic neuron and the synthesis of neurotransmitters. For example, α-methyltyrosine and carbidopa target specific enzymes involved in catecholamine synthesis. α-methyltyrosine inhibits the enzyme tyrosine hydroxylase, which converts tyrosine into dopamine. By blocking this enzyme, α-methyltyrosine reduces dopamine production and other catecholamines. Carbidopa, on the other hand, inhibits the enzyme dopa decarboxylase,...
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Drug Delivery: Overview01:16

Drug Delivery: Overview

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

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Hydrogels Based Drug Delivery Synthesis, Characterization and Administration.

Anca Onaciu1, Raluca Andrada Munteanu1, Alin Iulian Moldovan1,2

  • 1Medfuture-Research Center for Advanced Medicine, "Iuliu Hațieganu" University of Medicine and Pharmacy, Marinescu 23/Pasteur 4-6 Street, 400337 Cluj-Napoca, Romania.

Pharmaceutics
|August 28, 2019
PubMed
Summary

Hydrogels are versatile 3D networks with porous structures, ideal for drug delivery systems. Their biocompatibility and controlled release show promise for future targeted therapies.

Keywords:
biocompatibilitydrug deliveryhydrogelsin vivo administrationpolymerstarget therapy

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Drug Delivery

Background:

  • Hydrogels are 3D polymeric networks with porous structures.
  • They can swell and entrap large quantities of therapeutic agents and molecules.
  • Key properties include biocompatibility, biodegradability, and controlled release.

Purpose of the Study:

  • To highlight the potential of hydrogels as drug delivery systems.
  • To discuss their effectiveness in various medical applications.
  • To present their promise in future targeted therapy strategies.

Main Methods:

  • Review of existing literature on hydrogel applications.
  • Analysis of in vivo studies demonstrating therapeutic effects.
  • Evaluation of clinical trial outcomes.

Main Results:

  • Hydrogels demonstrate significant potential as drug delivery systems.
  • In vivo studies confirm their effectiveness as curing platforms.
  • Clinical trials show encouraging and promising results.

Conclusions:

  • Hydrogels are advanced biomaterials for drug delivery.
  • Their properties support applications in treating various diseases.
  • They represent a promising avenue for future targeted therapies.