Risk of Acute Lymphoblastic Leukemia: Results of a Case-Control Study

Background: Acute lymphoblastic leukemia (ALL) is the most common malignancy in children. Different environmental factors might be effective in the occurrence of this malignancy during childhood. The aim of this study was to find environmental risk factors in childhood ALL in Hamadan, Iran. Methods: This case-control study was done in 2015-2018 on 125 children younger than 15 years of age suffering from ALL. Patients were matched with 130 controls with respect to age, gender, and residence location. The identification of risk factors for ALL was sought based on the comparison of studied variables between case and control individuals. Results: A statistically significant increased risk for ALL was found with regard to type of delivery (OR: 0.43, 95% CI: 0.20 - 0.92, p˂0.02), childcare (OR: 4.58, 95% CI: 0.95 - 22.20, p˂0.04), birth weight (OR: 1.44, 95% CI: 1.53 - 2.21, p˂0.006), father’s education level (OR: 2.67, 95% CI: 1.10 - 6.45, p˂0.02), and father’s job (OR: 0.2 95% CI: 0.08 - 0.51, p˂0.001). Also observed were increased odds for ALL regarding male gender, mother’s high education level, mother’s freelance job, and medium or high family income. No association with ALL incidence was observed for age, gender, breastfeeding, mother’s age at pregnancy, malignancy in first- or second-degree relatives, or mother’s use of hair dye during pregnancy (p> 0.05). Conclusion: This study showed that father’s education level, father’s job, delivery type, birth weight, and childcare can play a role in the incidence of childhood ALL.