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Effect of sevoflurane treatment on microglia activation, NF-kB and MAPK activities

Xiangdi Yu1, Fangxiang Zhang1, Jinshan Shi1

  • 1Department of Anesthesiology, Guizhou Provincial People's Hospital, Guiyang, China.

Immunobiology
|August 28, 2019
PubMed

Insights

Sevoflurane, an anti-inflammatory agent, reduces microglia activation and pro-inflammatory cytokine production. This study shows sevoflurane suppresses NF-κB and MAPK pathways, offering potential therapeutic benefits for neurodegenerative diseases.

Area of Science:

  • Neuroscience
  • Immunology
  • Pharmacology

Background:

  • Microglia activation is a key factor in neurodegenerative diseases.
  • Sevoflurane exhibits anti-inflammatory properties.

Purpose of the Study:

  • To investigate the effects of sevoflurane on lipopolysaccharides (LPS)-induced microglia activation.
  • To explore sevoflurane's impact on pro-inflammatory cytokine production and signaling pathways.

Main Methods:

  • Primary microglia cells were treated with sevoflurane before LPS exposure.
  • Microglia migration, cytokine production (TNF-α, IL-6, IL-8), and NF-κB/MAPK pathway activation were assessed.
  • In vivo studies examined cytokine production in rat brains.

Main Results:

  • Sevoflurane significantly reduced LPS-induced microglia migration.
  • Pro-inflammatory cytokine production was decreased both in vitro and in vivo.
  • Sevoflurane attenuated the activation of NF-κB and p38 MAPK signaling pathways.

Conclusions:

  • Sevoflurane effectively suppresses microglia activation.
  • The anti-inflammatory effects of sevoflurane are mediated through the inhibition of NF-κB and MAPK signaling pathways.
  • Sevoflurane shows potential as a therapeutic agent for neurodegenerative conditions involving microglia activation.
Keywords:
ActivationMAPKMicrogliaNF-kBSevoflurane

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