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Updated: Jan 20, 2026

A "Patient-Like" Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis
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Published on: October 24, 2015

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ICMT contributes to hepatocellular carcinoma growth, survival, migration and chemoresistance via multiple oncogenic

Jianguo Xu1, Ying Zhu2, Fang Wang2

  • 1Department of Liver Disease Center, Shenzhen Hospital, Southern Medical University, Shenzhen, Guangdong, China.

Biochemical and Biophysical Research Communications
|August 28, 2019
PubMed

Insights

Isoprenylcysteine carboxylmethyltransferase (Icmt) is elevated in hepatocellular carcinoma (HCC), driving tumor growth and chemoresistance. Inhibiting Icmt may enhance chemotherapy effectiveness for HCC patients.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Isoprenylcysteine carboxylmethyltransferase (Icmt) is crucial for prenylation of oncoproteins like Ras.
  • Its role in hepatocellular carcinoma (HCC) remains largely unexplored.
  • Icmt's impact on HCC growth, survival, migration, and chemoresistance is investigated.

Purpose of the Study:

  • To elucidate the expression, function, and mechanistic impact of Icmt in HCC.
  • To determine if Icmt can be a therapeutic target for HCC treatment.

Main Methods:

  • Expression analysis of Icmt in HCC patient tissues and cell lines.
  • In vitro studies involving Icmt depletion and overexpression in HCC cells.
  • Assessment of cell growth, migration, survival, apoptosis, and chemoresistance.
  • Investigation of downstream signaling pathways, including Ras/Raf/Mek/Erk and EMT.

Main Results:

  • Icmt protein levels are significantly elevated in approximately 70% of HCC tissues and cells.
  • Icmt depletion inhibits HCC cell growth, migration, and survival, while enhancing doxorubicin sensitivity.
  • Icmt inhibition suppresses Ras/Raf/Mek/Erk signaling and epithelial-mesenchymal transition (EMT).
  • Icmt overexpression promotes growth and migration in normal liver cells.

Conclusions:

  • Icmt plays a critical role in HCC progression and chemoresistance.
  • Targeting Icmt presents a promising strategy to improve chemotherapy efficacy in HCC patients with high Icmt expression.
Keywords:
ChemoresistanceEMTHepatocellular carcinomaIcmtRas

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