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Undernutrition in childhood: Clinically based assessment tools and biological markers: Where are we and where should
E Delvin1, D J Harrington2, E Levy3
1Sainte-Justine UHC Research Centre, Canada; Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, Canada.
Insights
Undernutrition remains a significant problem in pediatric hospitals, often going undetected due to varied assessment methods. Personalized medicine allows for advanced detection using micronutrient and metabolic marker analysis for better patient outcomes.
Area of Science:
- Pediatric Nutrition
- Clinical Biochemistry
- Personalized Medicine
Background:
- Undernutrition is prevalent in pediatric hospitals, linked to adverse outcomes and high costs.
- Current detection methods lack consensus, vary widely, and show poor sensitivity, especially in acute cases.
- Existing tools primarily focus on energy, neglecting crucial micronutrient assessments.
Purpose of the Study:
- To highlight the limitations of current pediatric undernutrition detection methods.
- To advocate for advanced diagnostic approaches in pediatric nutritional assessment.
- To propose integrating micronutrient and metabolic marker analysis into personalized nutritional workups.
Main Methods:
- Review of existing methodologies for detecting undernutrition in pediatric patients.
- Analysis of the shortcomings of traditional nutritional assessment tools.
- Proposal for a novel approach utilizing micronutrient and metabolic marker measurement.
Main Results:
- Current undernutrition detection methods in pediatric settings are inadequate.
- A significant gap exists in assessing specific micronutrient deficiencies.
- Technological advancements enable more precise and personalized nutritional status evaluation.
Conclusions:
- Personalized medicine offers opportunities to improve pediatric nutritional assessment beyond traditional methods.
- Measuring selected micronutrients and metabolic markers can enhance diagnostic accuracy.
- Tailored nutritional workup schemes are essential for optimizing patient care and outcomes.
Abstract:
Despite its association with poor clinical outcomes and increased hospital costs, as of today undernutrition still goes undetected in paediatric hospitals. The reported prevalence of undernutrition in paediatric patients varies considerably. This disparity is partly due to the diversity of methods for its detection and assessment, as well as to the lack of consensus regarding its definition. Several methods, based on varied combinations of morphology characteristics, estimated nutritional intakes and medical conditions have been developed during the last 25 years. However, these tools suffer from poor sensitivity and selectivity particularly in acute conditions. Also while having their own merit, these tools mainly view malnutrition from the energy standpoint, disregarding assessment of specific micronutrients such as minerals and vitamins. In this position paper we make the point that in the era of personalized medicine, present technology offers the possibility of going beyond the traditional nutritional tools for assessing patients' status, and propose the measurement of selected micronutrients and allied metabolic markers in nutritional workup schemes adapted to each clinical condition.
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