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Updated: Jan 20, 2026

Imaging the Human Immunological Synapse
Published on: December 26, 2019
The Sweet Kiss Breaching Immunological Self-Tolerance
Mario Galgani1, Giuseppe Matarese2
1Istituto per l'Endocrinologia e l'Oncologia Sperimentale del Consiglio Nazionale delle Ricerche (IEOS-CNR), 80131 Napoli, Italy.
Abstract:
Metabolic alterations leading to overactivation of nutrient-energy-sensing pathways have been linked to altered immunological self-tolerance. Now, Zhang and colleagues (Immunity, 2019) have identified a key role for high glucose consumption in exacerbating autoimmunity in mice via induction of T helper (Th)17 cells. This reveals a novel mechanism underlying effects of diet during autoimmunity development with major translational implications.
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