Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Cell Death01:30

Overview of Cell Death

9.5K
Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...
9.5K
Autophagic Cell Death01:18

Autophagic Cell Death

4.4K
Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
4.4K
Adult Stem Cells01:33

Adult Stem Cells

33.4K
Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
33.4K
What are Cells?01:07

What are Cells?

197.2K
Cells are the smallest and basic units of life, whether it is a single cell that forms the entire organism, e.g., in a bacterium or trillions of them, e.g., in humans. No matter what organism a cell is a part of, they share specific characteristics.
Basic Characteristics of Cells
A living cell has a plasma membrane, a bilayer of lipids that separates the aqueous solution inside the cell called the cytoplasm from the outside environment.
Furthermore, a living cell possesses genetic information...
197.2K
Concentration Cells02:41

Concentration Cells

25.6K
A concentration cell is a type of a  voltaic cell constructed by connecting two almost identical half-cells, both based on the same half-reaction and using the same electrode, differing only in the concentration of one redox species. A concentration cell's potential, therefore, is determined only by the concentration difference of the particular redox species.
Consider the following voltaic cell:
25.6K
What is Cell Signaling?02:03

What is Cell Signaling?

129.8K
Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate to respond to the environment.
129.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Author Correction: Fc-engineered large molecules targeting blood-brain barrier transferrin receptor and CD98hc have distinct central nervous system and peripheral biodistribution.

Nature communications·2026
Same author

Therapeutic targeting of neuroimmune mechanisms in neurodegeneration.

Nature reviews. Drug discovery·2026
Same author

TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism.

Nature communications·2026
Same author

Loss of PILRA promotes microglial immunometabolism to reduce amyloid pathology in cell and mouse models of Alzheimer's disease.

Science translational medicine·2025
Same author

Early intervention anti-Aβ immunotherapy attenuates microglial activation without inducing exhaustion at residual plaques.

Molecular neurodegeneration·2025
Same author

Investigational eIF2B activator DNL343 modulates the integrated stress response in preclinical models of TDP-43 pathology and individuals with ALS in a randomized clinical trial.

Nature communications·2025

Related Experiment Video

Updated: Jan 20, 2026

Mass Histology to Quantify Neurodegeneration in Drosophila
06:34

Mass Histology to Quantify Neurodegeneration in Drosophila

Published on: December 15, 2016

10.7K

Cell Death and Neurodegeneration.

Benjamin J Andreone1, Martin Larhammar1, Joseph W Lewcock1

  • 1Denali Therapeutics, South San Francisco, California 94080, USA.

Cold Spring Harbor Perspectives in Biology
|August 28, 2019
PubMed
Summary

Understanding neurodegenerative disease requires knowledge of nerve cell death mechanisms. This review explores molecular pathways and stressors involved in neuronal loss, crucial for developing new treatments.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Pathology

Background:

  • Neurodegenerative diseases involve progressive neuronal dysfunction and loss.
  • Altered cellular homeostasis contributes to neurodegeneration.
  • Effective treatments are lacking due to incomplete understanding of disease mechanisms.

Purpose of the Study:

  • To review current knowledge on neuronal cell death mechanisms.
  • To link neuronal cell death pathways to neurodegenerative disease pathology.
  • To identify potential avenues for clinical intervention.

Main Methods:

  • Literature review of molecular signaling pathways in neuronal loss.
  • Analysis of upstream cell biology regulating these pathways.
  • Discussion of intrinsic and extrinsic stressors causing neuronal death in disease.

More Related Videos

Use of LysoTracker to Detect Programmed Cell Death in Embryos and Differentiating Embryonic Stem Cells
12:44

Use of LysoTracker to Detect Programmed Cell Death in Embryos and Differentiating Embryonic Stem Cells

Published on: October 11, 2012

23.9K
Author Spotlight: A Streamlined Approach to Studying Cell Death Initiation in Hypersensitive Response
06:06

Author Spotlight: A Streamlined Approach to Studying Cell Death Initiation in Hypersensitive Response

Published on: November 10, 2023

2.0K

Related Experiment Videos

Last Updated: Jan 20, 2026

Mass Histology to Quantify Neurodegeneration in Drosophila
06:34

Mass Histology to Quantify Neurodegeneration in Drosophila

Published on: December 15, 2016

10.7K
Use of LysoTracker to Detect Programmed Cell Death in Embryos and Differentiating Embryonic Stem Cells
12:44

Use of LysoTracker to Detect Programmed Cell Death in Embryos and Differentiating Embryonic Stem Cells

Published on: October 11, 2012

23.9K
Author Spotlight: A Streamlined Approach to Studying Cell Death Initiation in Hypersensitive Response
06:06

Author Spotlight: A Streamlined Approach to Studying Cell Death Initiation in Hypersensitive Response

Published on: November 10, 2023

2.0K

Main Results:

  • Key molecular signaling pathways driving neuronal loss are identified.
  • Upstream cellular mechanisms activating these pathways are highlighted.
  • The role of various stressors in disease-related neuronal death is discussed.

Conclusions:

  • Understanding neuronal cell death is critical for neurodegenerative disease research.
  • Elucidating molecular mechanisms of neuronal dysfunction and death offers therapeutic targets.
  • This knowledge is essential for developing disease-modifying treatments.