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Treatment Failure of Isavuconazole in a Patient with Cryptococcosis
Kathleen A Linder1,2, Tejal N Gandhi1, Marisa H Miceli3
1Division of Infectious Diseases, University of Michigan Medical School, 1500 E. Medical Dr., South University Hospital F4005, Ann Arbor, MI, 48109-5378, USA.
Abstract:
Isavuconazole is a broad-spectrum azole that is FDA-approved for the treatment of aspergillosis and mucormycosis; data on the use of isavuconazole for the treatment and prevention of other invasive fungal infections are limited. Here, we report a patient with pulmonary cryptococcosis treated with isavuconazole who experienced progression to disseminated infection with Cryptococcus while on isavuconazole. Caution is advised when using isavuconazole in situations where there is a paucity of data to recommend its use.
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