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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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The two main cell...
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Adult Stem Cells01:33

Adult Stem Cells

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Embryonic Stem Cells00:58

Embryonic Stem Cells

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Embryonic Stem Cells00:57

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
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Induced Pluripotent Stem Cells01:13

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Gene Therapy00:59

Gene Therapy

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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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CRISPR/Cas9 Gene Editing of Hematopoietic Stem and Progenitor Cells for Gene Therapy Applications
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Stem Cell Therapy: Curcumin Does the Trick.

Simin Sharifi1, Sepideh Zununi Vahed2, Elham Ahmadian2

  • 1Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Phytotherapy Research : PTR
|August 28, 2019
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Curcumin, a compound from turmeric, shows promise in protecting and stimulating stem cells. This review highlights its antioxidant, anti-aging, and regenerative potential for various health applications.

Keywords:
curcumindifferentiationstem cell

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Area of Science:

  • Biochemistry
  • Cell Biology
  • Pharmacology

Background:

  • Curcumin is a bioactive phytochemical with known anti-inflammatory, antioxidant, and anticancer properties.
  • Stem cells possess unique regenerative capabilities, including self-renewal and multipotency, with potential for differentiation.
  • The interaction between curcumin and stem cells warrants further investigation for therapeutic applications.

Purpose of the Study:

  • To review the multifaceted effects of curcumin on stem cells.
  • To explore curcumin's role in stem cell protection, proliferation, and differentiation.
  • To summarize curcumin's antioxidant, stemness, anti-aging, neuroprotective, and regenerative properties.

Main Methods:

  • Literature review of existing studies on curcumin and stem cells.
  • Analysis of research focusing on curcumin's biochemical and cellular mechanisms.
  • Synthesis of findings related to curcumin's impact on stem cell behavior and therapeutic potential.

Main Results:

  • Curcumin exhibits significant antioxidant and anti-inflammatory effects, protecting stem cells from damage.
  • Curcumin can stimulate stem cell proliferation and promote their differentiation into specific cell types.
  • Evidence suggests curcumin possesses anti-aging, neuroprotective, and wound-healing properties mediated through stem cell modulation.

Conclusions:

  • Curcumin demonstrates considerable potential as a therapeutic agent by modulating stem cell functions.
  • Its protective and stimulatory effects on stem cells highlight its relevance in regenerative medicine and anti-aging strategies.
  • Further research is needed to fully elucidate the mechanisms and clinical applications of curcumin in stem cell therapy.