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Renal perfusion imaging by MRI.

Jeff L Zhang1, Vivian S Lee2

  • 1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Journal of Magnetic Resonance Imaging : JMRI
|August 28, 2019
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Summary
This summary is machine-generated.

This review highlights advances in renal perfusion MRI over five years. Dynamic contrast-enhanced (DCE) MRI is used for tumors, while arterial spin labeling (ASL) shows promise for other kidney diseases, pending standardization.

Keywords:
arterial spin labelingdynamic contrast enhancedintra-voxel incoherent motionkidneyperfusion

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Area of Science:

  • Magnetic Resonance Imaging (MRI)
  • Renal Physiology
  • Medical Imaging Technology

Background:

  • Quantitative assessment of renal perfusion is crucial for diagnosing and managing kidney diseases.
  • Multiple MRI techniques, including DCE-MRI, ASL, and IVIM-DWI, offer quantitative insights into renal blood flow.
  • Recent advancements have expanded the utility of these MRI methods in clinical and preclinical settings.

Purpose of the Study:

  • To review recent advancements (past 5 years) in renal perfusion MRI techniques.
  • To discuss technical developments and clinical/preclinical applications of renal perfusion MRI.
  • To identify areas for future research and clinical implementation.

Main Methods:

  • Review of literature on renal perfusion MRI published within the last five years.
  • Focus on dynamic contrast-enhanced (DCE) MRI, arterial spin labeling (ASL), and intravoxel incoherent motion (IVIM) analysis.
  • Examination of applications in chronic kidney disease, renal transplantation, and renal tumors.

Main Results:

  • DCE-MRI is established for renal tumor assessment but less utilized for other renal diseases.
  • ASL MRI, a non-contrast technique, demonstrates significant potential in both preclinical and clinical renal applications.
  • Diffusion-weighted imaging with IVIM analysis offers complementary perfusion information.

Conclusions:

  • Standardization of MRI protocols for renal perfusion assessment is essential for widespread clinical adoption.
  • Further large-scale clinical trials are needed to validate these techniques before broad implementation.
  • Renal perfusion MRI holds great promise for improving the diagnosis and management of various kidney conditions.