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Hepatitis C Treatment Differences in Elderly Patients: Single-Center Retrospective Study
Kamran Qureshi1, Tess Petersen2, Jennifer Andres3
1Saint Louis University School of Medicine, MO, USA.
The Annals of Pharmacotherapy
|August 28, 2019
Summary
Elderly patients over 70 with hepatitis C virus (HCV) experienced lower treatment success rates with direct-acting antivirals (DAAs). This highlights the need for early HCV treatment before liver cirrhosis develops.
Area of Science:
- Hepatology
- Virology
- Geriatric Medicine
Background:
- Direct-acting antivirals (DAAs) demonstrate high efficacy for hepatitis C virus (HCV) treatment (>90% SVR12).
- Limited data exist on DAA efficacy in elderly populations (>70 years).
Purpose of the Study:
- To compare DAA treatment outcomes between elderly and nonelderly HCV patients.
- To identify factors influencing treatment success in different age groups.
Main Methods:
- Retrospective cohort study of 551 HCV patients treated with DAAs (June 2014 - Sept 2016).
- Patients categorized as elderly (≥70 years) or nonelderly (<70 years).
- Primary outcome: sustained virological response at 12 weeks (SVR12).
Main Results:
- SVR12 rates were significantly lower in the elderly group (81%) compared to the nonelderly group (95%).
- Elderly patients with liver cirrhosis showed particularly low SVR12 rates (69.4% vs. 94.1% in nonelderly cirrhotic patients).
- Age >70 and cirrhosis were the strongest predictors of treatment failure.
Conclusions:
- Elderly patients, especially those with cirrhosis, have reduced SVR12 rates with DAAs.
- Early HCV treatment is crucial to prevent cirrhosis and its associated complications.
- Consideration of age and liver status is vital for optimizing HCV treatment strategies.
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