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Localization of the 68,000-Da human neurofilament gene (NF68) using a murine cDNA probe
M J Somerville1, D R McLachlan, M E Percy
1Department of Physiology, University of Toronto, Ont., Canada.
Genome
|August 1, 1988
Abstract:
A recent investigation, using a human genomic probe, has indicated that the 68,000 dalton neurofilament gene (NF68) is on the short arm of chromosome 8. We have used a murine cDNA probe on 65 metaphase spreads in situ to localize the human NF68 gene to 8p21 (20/370 grains; p less than 0.0001). In addition, we have found secondary hybridization sites at the centromeric region of chromosome 2 and the long arm of chromosome 7, which are putative loci for other intermediate filaments.