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Notch and breast cancer metastasis: Current knowledge, new sights and targeted therapy

Yu Zhang1, Zi-Yan Xie1, Xuan-Tong Guo1

  • 1Department of Pathophysiology, Medical College, Nanchang University, Nanchang, Jiangxi 330006, P.R. China.

Oncology Letters
|August 28, 2019
PubMed

Insights

Notch signaling drives breast cancer metastasis by promoting disseminated tumor cells (DTCs) survival, motility, and colonization. Understanding these mechanisms can lead to new therapies to reduce metastasis and improve patient outcomes.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Breast cancer is the most common invasive cancer in women.
  • Metastasis is a primary cause of breast cancer mortality.
  • Disseminated tumor cells (DTCs) initiate the metastatic cascade.

Purpose of the Study:

  • To review the mechanisms of Notch signaling in breast cancer metastasis.
  • To elucidate Notch's role in DTC occurrence, motility, and colonization.
  • To highlight Notch-targeted therapies for improved patient prognosis.

Main Methods:

  • Literature review of studies on Notch signaling and breast cancer metastasis.
  • Analysis of Notch pathway involvement in DTCs.
  • Examination of tumor microenvironment interactions and host surveillance evasion.

Main Results:

  • Notch signaling is crucial for DTC survival and dissemination.
  • Notch enhances DTC motility and interaction with the microenvironment.
  • The pathway facilitates secondary colonization and metastasis.

Conclusions:

  • Notch signaling plays a multifaceted role in breast cancer metastasis.
  • Targeting the Notch pathway offers potential therapeutic strategies.
  • Further research can improve treatment and patient outcomes for metastatic breast cancer.
Keywords:
Delta like canonical notch ligand 4Jagged-1Notchbreast cancermetastasis

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