Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammation01:38

Inflammation

61.8K
Overview
61.8K
Longitudinal Research02:20

Longitudinal Research

13.1K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
13.1K
Intellectual Disability01:29

Intellectual Disability

659
Intellectual disability (ID) is a neurodevelopmental condition characterized by deficits in intellectual and adaptive functioning that manifest during the developmental period. This condition encompasses challenges in reasoning, memory, problem-solving, and learning, accompanied by impairments in everyday life skills, such as communication, self-care, and social interactions. Intellectual disability affects approximately 1% of the population in the United States, impacting an estimated 5...
659
Learning Disabilities01:25

Learning Disabilities

579
Learning disabilities are cognitive disorders caused by neurological impairments that affect cognitive functions like language and reading, without indicating overall intellectual or developmental challenges. These disabilities differ from global intellectual or developmental disabilities as they are limited to distinct cognitive functions. Common learning disabilities include dysgraphia, dyslexia, and dyscalculia, each of which impacts unique aspects of learning.
Dyslexia
Dyslexia is a...
579
Longitudinal Studies01:26

Longitudinal Studies

481
Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
481
Receptor-mediated Endocytosis01:39

Receptor-mediated Endocytosis

110.6K
Overview
110.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Predictors of Word Learning With and Without Retrieval Practice in Children With Developmental Language Disorder.

Journal of speech, language, and hearing research : JSLHR·2026
Same author

A Taxonomy of Data Synthesis.

Personality & social psychology bulletin·2026
Same author

Accentuating the Positive: Contribution of Positive Relations With Others and Daily Interpersonal Interactions to Longevity.

Biopsychosocial science and medicine·2026
Same author

Is my loneliness killing me? Effects of loneliness and social isolation on transitions between cognitive status categories and death.

Journal of personality and social psychology·2026
Same author

Association of Physical Activity and Gait Speed: Does Context Matter?

American journal of lifestyle medicine·2026
Same author

The 2008 Great Recession Lowered Americans' Class Identity.

Psychological science·2025

Related Experiment Video

Updated: Jan 20, 2026

Fluorescence-mediated Tomography for the Detection and Quantification of Macrophage-related Murine Intestinal Inflammation
07:05

Fluorescence-mediated Tomography for the Detection and Quantification of Macrophage-related Murine Intestinal Inflammation

Published on: December 15, 2017

8.7K

Multimorbidity, inflammation, and disability: a longitudinal mediational analysis.

Elliot M Friedman1, Daniel K Mroczek2, Sharon L Christ3

  • 1Department of Human Development and Family Studies, Purdue University, 1202 West State Street, West Lafayette, IN 47907, USA.

Therapeutic Advances in Chronic Disease
|August 28, 2019
PubMed
Summary

Systemic inflammation partially explains how having multiple chronic conditions (multimorbidity) leads to increased functional limitations over time. This inflammation links multimorbidity to worsening, but not new, limitations.

Keywords:
Multimorbidityfunctional limitationsinflammationlongitudinalmediation

More Related Videos

In vivo Imaging Method to Distinguish Acute and Chronic Inflammation
07:10

In vivo Imaging Method to Distinguish Acute and Chronic Inflammation

Published on: August 16, 2013

20.7K
Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model
09:11

Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model

Published on: February 14, 2021

10.5K

Related Experiment Videos

Last Updated: Jan 20, 2026

Fluorescence-mediated Tomography for the Detection and Quantification of Macrophage-related Murine Intestinal Inflammation
07:05

Fluorescence-mediated Tomography for the Detection and Quantification of Macrophage-related Murine Intestinal Inflammation

Published on: December 15, 2017

8.7K
In vivo Imaging Method to Distinguish Acute and Chronic Inflammation
07:10

In vivo Imaging Method to Distinguish Acute and Chronic Inflammation

Published on: August 16, 2013

20.7K
Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model
09:11

Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model

Published on: February 14, 2021

10.5K

Area of Science:

  • Gerontology
  • Public Health
  • Biomedical Science

Background:

  • Longitudinal data from the Survey of Mid-Life Development in the United States was utilized.
  • Examined systemic inflammation's role in linking multimorbidity to functional limitations.

Purpose of the Study:

  • Investigate inflammation as a mediator between multimorbidity and functional limitations.
  • Analyze the impact of multimorbidity on the onset and progression of functional limitations over 17-19 years.

Main Methods:

  • Assessed chronic conditions and functional limitations via questionnaires.
  • Measured serum levels of Interleukin-6, C-reactive protein, and fibrinogen.
  • Employed structural equation models to determine mediation by inflammation.

Main Results:

  • Multimorbidity significantly predicted increased functional limitations and onset.
  • Inflammation partially mediated the relationship between multimorbidity and changes in functional limitations.
  • No significant mediation by inflammation was found for the onset of limitations.

Conclusions:

  • Systemic inflammation, a marker for multiple conditions, partially explains why multimorbidity is disabling.
  • Findings highlight inflammation's role in the functional decline associated with multiple chronic diseases.