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Vascularized drusen: a cross-sectional study.

Chris Or1, Jeffrey S Heier2, David Boyer3

  • 11New England Eye Center, Tufts Medical Center, 260 Tremont Street, Biewend Building, 9-11th Floor, Boston, MA 02111 USA.

International Journal of Retina and Vitreous
|August 28, 2019
PubMed
Summary
This summary is machine-generated.

Optical coherence tomography angiography (OCTA) detected vascularized drusen in 5.5% of intermediate age-related macular degeneration (AMD) patients before exudation. This finding highlights OCTA

Keywords:
Age-related macular degenerationOptical coherence tomographyOptical coherence tomography angiographyRetinaRetinal imagingVascularized drusen

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Retinal Diseases

Background:

  • Histopathologic studies suggest neovascularization can occur within drusen in age-related macular degeneration (AMD).
  • Detecting this neovascularization before exudation is crucial for understanding AMD progression.
  • Optical coherence tomography angiography (OCTA) offers a potential non-invasive method for in vivo visualization.

Purpose of the Study:

  • To investigate the presence and prevalence of neovascularization within drusen using OCTA in patients with intermediate non-exudative AMD.
  • To assess if OCTA can detect neovascularization in drusen prior to the development of exudative AMD.

Main Methods:

  • Retrospective cross-sectional study analyzing 128 patients with intermediate AMD.
  • Patients had exudative AMD in one eye and intermediate non-exudative AMD in the fellow eye.
  • Data collected between September 2015 and March 2017 from multiple tertiary referral retina clinics.

Main Results:

  • SD-OCTA identified vascularized drusen in 7 out of 128 eyes (5.5% prevalence).
  • Twelve instances of vascularized drusen were observed, predominantly in parafoveal/subfoveal regions.
  • Fundus angiography (FA) failed to detect the neovascular nature of these vascularized drusen.

Conclusions:

  • SD-OCTA is a valuable tool for diagnosing vascularized drusen in intermediate non-exudative AMD.
  • These findings suggest vascularized drusen may represent an early stage of AMD progression.
  • Further longitudinal studies are required to understand the evolution and conversion risk of these lesions.