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Application of microfluidic chip technology in pharmaceutical analysis: A review
Ping Cui1,2, Sicen Wang1,2
1School of Pharmacy, Xi'an Jiaotong University Health Science Center, #76, Yanta West Road, Xi'an 710061, China.
Journal of Pharmaceutical Analysis
|August 28, 2019
Summary
Microfluidic technologies offer innovative solutions for pharmaceutical analysis, enabling high-throughput drug screening and metabolism studies. These lab-on-a-chip advancements are revolutionizing drug development and mechanistic investigations.
Area of Science:
- Pharmaceutical analysis
- Microfluidics
- Drug development
Background:
- Pharmaceutical analytical methods are crucial for drug development.
- Microfluidics and microfabrication offer novel drug analysis approaches.
- Technologies like lab-on-a-chip, 3D cell culture, and organs-on-chip have advanced rapidly.
Purpose of the Study:
- To review microfluidic technologies for drug analysis from 2010-2018.
- To discuss the potential future development of microfluidics in drug analysis.
Main Methods:
- Review of recent literature (2010-2018) on microfluidic applications in drug analysis.
- Highlighting microfluidic chip technologies (lab-on-a-chip, 3D cell culture, organs-on-chip, droplet techniques).
- Integration of microfluidic chips with detection techniques for drug screening and analysis.
Main Results:
- Microfluidic chips enable high-throughput screening, detection, and mechanistic studies of drugs.
- Various microfluidic techniques are suitable for comprehensive drug analysis.
- Significant advancements in microfluidic technologies for pharmaceutical applications have been observed.
Conclusions:
- Microfluidic technologies represent a significant advancement in pharmaceutical analytical methods.
- These technologies hold great potential for future drug development and analysis.
- Continued innovation in microfluidics will further enhance drug screening, testing, and metabolism studies.
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