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A new handheld quantitative micro-elastography (QME) probe enables faster, artifact-free tissue imaging. This optical coherence elastography (OCE) device can distinguish cancerous from benign breast tissue, paving the way for clinical use.

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Area of Science:

  • Biomedical Engineering
  • Medical Imaging
  • Optical Coherence Tomography

Background:

  • Optical coherence elastography (OCE) shows clinical potential but is limited by bulky, lab-based systems.
  • Compact handheld devices face challenges with slow scan rates and motion artifacts.

Purpose of the Study:

  • To develop a compact, handheld quantitative micro-elastography (QME) probe for accelerated clinical translation.
  • To overcome motion artifacts and improve scan speed in handheld OCE devices.

Main Methods:

  • Developed a handheld QME probe with a novel acquisition protocol using a custom bidirectional scan pattern and MEMS scanner.
  • Synchronized microelectromechanical system (MEMS) scanner with annular PZT actuator for sample deformation.
  • Implemented a scan pattern to reduce acquisition time and minimize motion artifact in displacement map generation.

Main Results:

  • Achieved a scan volume of 6 × 6 × 1 mm in 3.4 seconds with the handheld QME probe.
  • Demonstrated comparable image quality to bench-mounted systems using tissue-mimicking phantoms.
  • Successfully performed handheld QME on human breast tissue, distinguishing cancerous from benign tissue, validated by histology.

Conclusions:

  • The handheld QME probe is feasible for clinical applications, offering improved speed and reduced motion artifacts.
  • This technology enables quantitative elastography in a portable format, facilitating clinical translation.
  • Handheld QME successfully differentiates malignant from benign breast tissue, supporting its diagnostic potential.