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Published on: February 25, 2007
Acupressure to Reduce Treatment-Related Symptoms for Children With Cancer and Recipients of Hematopoietic Stem Cell
E Anne Lown1, Anu Banerjee2, Eric Vittinghoff3
1Social and Behavioral Sciences, School of Nursing, University of California, San Francisco, California.
Insights
This study explored acupressure for children undergoing cancer treatment or stem cell transplants. Acupressure may help manage treatment side effects like nausea and pain in pediatric patients.
Area of Science:
- Pediatric Oncology
- Integrative Medicine
- Clinical Trials
Background:
- A pragmatic randomized controlled trial (RCT) named Acupressure for Children in Treatment for a Childhood Cancer (ACT-CC) was designed.
- The study protocol focuses on evaluating acupressure's role in managing symptoms for children undergoing cancer treatment or hematopoietic stem cell transplant (HSCT).
Purpose of the Study:
- To assess the feasibility and effectiveness of an acupressure intervention.
- To reduce treatment-related symptoms in pediatric cancer patients and HSCT recipients.
Main Methods:
- A two-armed RCT involving 85 children and their caregivers across two pediatric teaching hospitals.
- Participants were randomized to receive usual care plus daily professional and caregiver-delivered acupressure or usual care alone.
- The intervention included up to 20 professional acupressure treatments.
Main Results:
- The primary outcome was a composite measure of nausea and vomiting in children.
- Secondary outcomes included child's nausea, vomiting, pain, fatigue, depression, anxiety, and positive affect.
- Parental outcomes such as depression, anxiety, posttraumatic stress symptoms, and self-efficacy were also assessed.
Conclusions:
- The trial results can inform childhood cancer and HSCT centers on integrating acupressure providers for symptom management.
- This research could guide the routine inclusion of acupressure to improve patient care and outcomes.
Background:
We describe the study design and protocol of a pragmatic randomized controlled trial (RCT) Acupressure for Children in Treatment for a Childhood Cancer (ACT-CC).
Objective:
To describe the feasibility and effectiveness of an acupressure intervention to decrease treatment-related symptoms in children in treatment for cancer or recipients of a chemotherapy-based hematopoietic stem cell transplant (HSCT).
Design:
Two-armed RCTs with enrollment of 5 to 30 study days.
Setting:
Two pediatric teaching hospitals.
Patients:
Eighty-five children receiving cancer treatment or a chemotherapy-based HSCT each with 1 parent or caregiver.
Intervention:
Patients are randomized 1:1 to receive either usual care plus daily professional acupressure and caregiver delivered acupressure versus usual care alone for symptom management. Participants receive up to 20 professional treatments.
Main Outcome:
A composite nausea/vomiting measure for the child.
Secondary Outcomes:
Child's nausea, vomiting, pain, fatigue, depression, anxiety, and positive affect.
Parent Outcomes:
Depression, anxiety, posttraumatic stress symptoms, caregiver self-efficacy, and positive affect. Feasibility of delivering the semistandardized intervention will be described. Linear mixed models will be used to compare outcomes between arms in children and parents, allowing for variability in diagnosis, treatment, and age.
Discussion:
Trial results could help childhood cancer and HSCT treatment centers decide about the regular inclusion of trained acupressure providers to support symptom management.
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