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Reduction of intratumoral brain perfusion by noninvasive transcranial electrical stimulation

G Sprugnoli1, L Monti2, L Lippa3

  • 1Brain Investigation and Neuromodulation Laboratory, Department of Medicine, Surgery and Neuroscience, Unit of Neurology and Clinical Neurophysiology, Siena Medical School, Siena, Italy.

Science Advances
|August 28, 2019
PubMed

Insights

Transcranial electrical stimulation (tES) safely and noninvasively reduced blood flow in human brain tumors. This novel approach may offer a new therapeutic option for glioblastoma and metastasis treatment.

Area of Science:

  • Neurosurgery
  • Oncology
  • Biophysics

Background:

  • Malignant brain tumors have a poor prognosis.
  • Tumor perfusion reduction can induce necrosis, suggesting a therapeutic strategy.
  • Electrical stimulation shows promise in preclinical models for reducing tumor perfusion.

Purpose of the Study:

  • To investigate the safety and efficacy of transcranial electrical stimulation (tES) in reducing intratumoral perfusion in human brain tumors.
  • To assess the feasibility of tES as a noninvasive therapeutic option for patients with brain tumors.

Main Methods:

  • Selected patients with glioblastoma or metastasis underwent multichannel tES.
  • Personalized biophysical modeling guided tES application to target the tumor.
  • Perfusion was assessed using magnetic resonance imaging (MRI).

Main Results:

  • tES was safely tolerated by all patients without adverse effects.
  • tES selectively reduced perfusion within the solid tumor mass.
  • The procedure demonstrated feasibility in a clinical setting.

Conclusions:

  • Transcranial electrical stimulation is a safe and noninvasive method to reduce brain tumor perfusion in humans.
  • tES holds potential as a standalone or combination therapy for brain tumors.
  • Further research may establish tES as a valuable tool in neuro-oncology.

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