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Updated: Jan 20, 2026
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Real-time X-ray Imaging of Lung Fluid Volumes in Neonatal Mouse Lung
Published on: July 18, 2016
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Volume Guaranteed Ventilation During Neonatal Transport.
Gusztav Belteki1,2, Andras Szell2, Lajos Lantos1,2
1Neonatal Intensive Care Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.
Summary
Synchronized intermittent mandatory ventilation with volume guarantee during neonatal transport reduced excessive tidal volumes and peak inflating pressures. However, it also led to a greater contribution of spontaneous breaths to minute ventilation compared to ventilation without volume guarantee.
Area of Science:
- Neonatal critical care
- Respiratory support
- Transport medicine
Background:
- Neonatal transport requires mechanical ventilation for critically ill infants.
- Synchronized intermittent mandatory ventilation (SIMV) is commonly used.
- Volume guarantee (VG) is a feature that aims to ensure consistent tidal volumes.
Purpose of the Study:
- To compare ventilator settings and outcomes in infants receiving SIMV with VG versus SIMV without VG during emergency neonatal transport.
- To evaluate the impact of VG on tidal volumes, inflating pressures, and ventilation distribution.
Main Methods:
- Retrospective observational study of 77 infants undergoing emergency neonatal transfer.
- Infants received SIMV with or without VG using a specific neonatal ventilator.
- Detailed ventilator data were collected and analyzed using Python.
Main Results:
- SIMV with VG resulted in lower and less variable expiratory tidal volumes (4.8 vs 6.0 mL/kg) and lower peak inflating pressures (15.5 vs 19.5 cm H2O) compared to SIMV without VG.
- The proportion of minute ventilation from ventilator inflations was lower with VG (66% vs 83%).
- Fewer infants in the VG group received tidal volumes >6 mL/kg or >8 mL/kg.
Conclusions:
- Volume guarantee during neonatal transport effectively reduces excessive tidal volumes and peak inflating pressures.
- VG ventilation is associated with a higher contribution of spontaneous breaths to minute ventilation.
- These findings suggest a potential benefit of VG in optimizing ventilation during neonatal transport.
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