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Updated: Jan 20, 2026
07:17
An Orthotopic Resectional Mouse Model of Pancreatic Cancer
Published on: September 24, 2020
12.3K
Meta-analysis of recurrence pattern after resection for pancreatic cancer
M Tanaka1, A L Mihaljevic1, P Probst1
1Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany.
The British Journal of Surgery
|August 28, 2019
Summary
Understanding initial recurrence patterns in pancreatic ductal adenocarcinoma (PDAC) post-surgery is key. This study identifies key factors linked to where PDAC initially recurs, aiding personalized patient follow-up strategies.
Area of Science:
- Oncology
- Surgical Oncology
- Gastroenterology
Background:
- Pancreatic ductal adenocarcinoma (PDAC) recurrence after resection impacts patient outcomes.
- Initial recurrence patterns are crucial for stratifying patients for postoperative follow-up.
Purpose of the Study:
- To systematically review and analyze initial recurrence patterns in resected PDAC.
- To correlate these recurrence patterns with clinicopathological factors.
Main Methods:
- Systematic search of MEDLINE and Web of Science databases.
- Meta-analysis of 89 studies including 17,313 patients.
- Calculation of pooled odds ratios and confidence intervals for clinicopathological factors.
Main Results:
- Initial recurrence rates: 20.8% locoregional, 26.5% liver, 11.4% lung, 13.5% peritoneal.
- R1 resection, perineural invasion, and positive cytology linked to peritoneal dissemination.
- Low tumor differentiation associated with liver recurrence.
Conclusions:
- Identifying risk factors for PDAC recurrence patterns can inform targeted surveillance.
- This knowledge aids in developing specific treatment strategies for pancreatic cancer patients post-surgery.
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