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Levering Mechanically Activated Piezo Channels for Potential Pharmacological Intervention

Bailong Xiao1

  • 1State Key Laboratory of Membrane Biology; Tsinghua-Peking Joint Center for Life Sciences; IDG/McGovern Institute for Brain Research; Beijing Advanced Innovation Center for Structural Biology; and School of Pharmaceutical Sciences, Tsinghua University, Beijing 100084, China;

Annual Review of Pharmacology and Toxicology
|August 28, 2019
PubMed
Summary

Piezo channels are crucial for converting mechanical forces into signals. Genetic and structural studies, along with identified activators like Yoda1, show Piezo channels are promising drug targets for various diseases.

Keywords:
Piezo1Piezo2drug discoveryion channelmechanotransduction

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