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Updated: Jan 20, 2026

Measurement of Survival Time in Brachionus Rotifers: Synchronization of Maternal Conditions
Published on: July 22, 2016
Estimation on conditional restricted mean survival time with counting process
Junshan Qiu1, Ennan Gu2, Dali Zhou3
1Division of Biometrics I, OB/OTS/CDER, US FDA , Silver Spring , Maryland , USA.
Abstract:
In traditional survival analyses, hazard ratio (HR) is commonly used to evaluate treatment effects. However, HR may not be easy to interpret. Restricted mean survival time is a viable alternative to HR, particularly when the proportional hazards assumption is not satisfied. We developed a conditional restricted mean survival time (CRMST) estimator for a time interval of interest using counting process. The variance of CRMST was estimated using a perturbation re-sampling method for asymptotic normality. The utility of our CRMST seems promising based on comprehensive simulation studies and a real data case study.
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