Selective targeting of signet ring cell adenocarcinomas
1Istinye University, Faculty of Pharmacy, İstinye Üniversitesi Topkapı Kampüsü, (Maltepe Mah., Edirne Çırpıcı Yolu, No. 9 Zeytinburnu), İstanbul 34010, Turkey.
Abstract:
Many epithelial tumors, especially signet-ring cell adenocarcinomas, produce huge amounts of mucin glycoproteins that fill cytoplasm and push nucleus to the periphery, giving a signet ring like structure to the cell. Mucin proteins are very rich of l-threonine which is essential in humans. L-threonine content can reach up to 35% of total amino acid composition of some mucin proteins. Therefore l-threonine can be the Achilles heel of signet ring cell adenocarcinomas which are one of the most malignant and agressive cancers. A modified bioisoster of l-threonine, 4-fluoro l-threonine (its fluorine can be radioactive or not), can be used to selectively kill signet ring cancer cells without harming normal cells or for diagnostic purposes.
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