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High pressure liquid chromatographic determination with ultraviolet detection of gentamicin and correlation with the
J W Van Duijn1, D M Barends, D W Groot
1National Institute for Quality Control of Drugs (RIGO), Leiden, The Netherlands.
Pharmaceutisch Weekblad. Scientific Edition
|December 9, 1988
Abstract:
The content of gentamicin in pharmaceuticals is measured by the high pressure liquid chromatographic technique described in the monographs for Gentamicin Sulphate and Gentamicin Injection in the British Pharmacopoeia 1980 for the determination of the composition of gentamicin. Calculation procedures are presented to transform this qualitative high pressure liquid chromatographic procedure for the assay of gentamicin so that it gives results in terms of potency. A comparison is made of this data with the results of the microbiological assay according to the European Pharmacopoeia.