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Syntenin: PDZ Protein Regulating Signaling Pathways and Cellular Functions
Tadayuki Shimada1, Shin Yasuda2, Hiroko Sugiura2
1Synaptic Plasticity Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan. shimada-td@igakuken.or.jp.
International Journal of Molecular Sciences
|August 29, 2019
Summary
Syntenin, a protein with PDZ domains, regulates cell membrane architecture. Increased syntenin levels are linked to tumor metastasis, neurite protrusion, and exosome biogenesis, highlighting its diverse cellular roles.
Area of Science:
- Molecular Biology
- Cell Biology
- Biochemistry
Background:
- Syntenin is an adaptor protein characterized by two tandem PDZ domains.
- These PDZ domains bind to various peptide motifs, mediating protein-protein interactions.
- Syntenin's interactions influence cell membrane structure and function.
Purpose of the Study:
- To review updated data on syntenin's roles in cellular processes.
- To highlight syntenin's involvement in neuronal synapses, tumor invasion, and exosome biogenesis.
Main Methods:
- Literature review of existing research on syntenin.
- Analysis of studies investigating syntenin's interactions and functional consequences.
Main Results:
- Syntenin's PDZ domains interact with numerous proteins.
- Elevated syntenin levels correlate with increased tumor cell metastasis.
- Syntenin regulates neurite protrusion in neuronal cells and exosome biogenesis.
Conclusions:
- Syntenin plays a critical role in regulating neuronal synapse architecture.
- Syntenin is implicated in controlling tumor cell invasion and metastasis.
- Syntenin is a key regulator of exosome biogenesis and release.
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