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Isolation and Characterization of Primary Rat Valve Interstitial Cells: A New Model to Study Aortic Valve Calcification
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Lipoprotein(a) Gene Polymorphism Increases a Risk Factor for Aortic Valve Calcification.

Ugur Ozkan1,2, Fatih Ozcelik1, Mustafa Yildiz3

  • 1Department of Cardiology, Faculty of Medicine, Trakya University, 22030 Edirne, Turkey.

Journal of Cardiovascular Development and Disease
|August 29, 2019
PubMed
Summary

Genetic and environmental factors contribute to calcific aortic valve disease (CAVD). This study identified smoking, high LDL, and specific gene variations as potential risk factors for developing calcific aortic stenosis.

Keywords:
Lp(a) levelcalcific aortic valve stenosisrs10455872rs3798220

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Area of Science:

  • Cardiovascular Medicine
  • Genetics
  • Biochemistry

Background:

  • Calcific aortic valve disease (CAVD) is a complex condition influenced by both genetic and environmental factors.
  • The disease spectrum ranges from mild valve thickening to severe calcification and stenosis, involving inflammation and lipoprotein deposition.
  • Its progression shares similarities with coronary artery disease.

Purpose of the Study:

  • To investigate the association between lipoprotein(a) [Lp(a)] levels, specific gene polymorphisms, and calcific aortic stenosis (CAS).
  • To identify potential genetic and environmental risk factors contributing to the development of CAS.

Main Methods:

  • Analyzed blood samples from 75 patients diagnosed with CAVD and 77 controls.
  • Assessed Lp(a) levels and screened for rs10455872 and rs3798220 gene polymorphisms.
  • Conducted pre-echocardiography blood tests to rule out other risk factors, including LDL, creatinine, and albumin levels.

Main Results:

  • Significant associations were found between smoking, elevated LDL cholesterol, elevated creatinine, low albumin levels, and Lp(a) levels in patients with CAVD.
  • Specific gene polymorphisms, namely rs10455872 and rs3798220, showed a significant association with calcific aortic stenosis.
  • These factors collectively suggest a multifactorial etiology for the disease.

Conclusions:

  • Smoking, dyslipidemia (elevated LDL), renal function (creatinine), nutritional status (albumin), and Lp(a) levels are significant risk factors for CAVD.
  • The identified gene polymorphisms (rs10455872, rs3798220) represent potential genetic contributors to the development of calcific aortic stenosis.
  • These findings highlight the interplay of environmental and genetic factors in the pathogenesis of CAVD.