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Growth of Microorganisms in Propofol and Mixture of Propofol, Lidocaine and Fentanyl

Hatice Aysel Altan1, Esat Bonabi2, Sevgi Kesici3

  • 1Department of Anesthesiology, Istanbul Aydin University, Vocational School of Health Services, Istanbul, Turkey.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|August 29, 2019
PubMed
Abstract

Insights

Lidocaine demonstrated antimicrobial properties, inhibiting microbial growth in propofol mixtures. However, fentanyl promoted growth, underscoring the need for aseptic techniques in propofol preparation.

Area of Science:

  • Microbiology
  • Pharmacology
  • Infectious Disease

Background:

  • Propofol is a widely used anesthetic agent.
  • Microbial contamination of propofol infusions is a significant clinical concern.
  • The combination of propofol with other drugs like fentanyl and lidocaine may influence its antimicrobial properties.

Purpose of the Study:

  • To evaluate the antimicrobial effects of propofol when combined with fentanyl and lidocaine.
  • To determine the impact of different temperatures and incubation times on microbial growth in these drug combinations.
  • To assess the potential for extending the safe use of propofol infusions.

Main Methods:

  • A cross-sectional study was conducted at Istanbul Aydin University Laboratory.
  • Microbial growth of Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans, and Acinetobacter baumanni was assessed.
  • Bacterial solutions were incubated at 4°C, 22°C, and 37°C for 0, 8, and 24 hours.

Main Results:

  • Propofol alone supported microbial growth.
  • The combination of propofol and fentanyl promoted microbial growth, particularly at room and body temperatures.
  • Lidocaine significantly reduced microbial growth in propofol-fentanyl mixtures, except for Candida albicans.

Conclusions:

  • Lidocaine exhibits an antimicrobial effect that can help prevent infections associated with propofol.
  • Fentanyl, similar to propofol, can promote microbial growth under certain conditions.
  • Maintaining aseptic techniques during the preparation of propofol infusions remains critical.

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