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Published on: October 31, 2025
A predictive model for extubation readiness in extremely preterm infants
Dhruv Gupta1, Rachel G Greenberg2, Amit Sharma1
1Department of Pediatrics, Wayne State University, Detroit, MI, USA.
Objective:
To develop an estimator for predicting successful extubation for an individual preterm infant.
Study Design:
This was a retrospective study that included infants with birth weights ≤1250 g, who were admitted to a tertiary NICU over a 7-year period, received mechanical ventilation and had an elective extubation attempt within 60 days of age. Perinatal and periextubation characteristics were compared in the successful and failed extubation groups.
Results:
Of 621 screened infants, 312 were included. Extubation succeeded in 73% and failed in 27%. Adjusted factors associated with successful extubation included greater gestational age, chronologic age, pre-extubation pH and lower pre-extubation FiO2, along with lower "peak" respiratory severity score in the first 6 h of age.
Conclusions:
We used readily available demographic and clinical data to create an extubation readiness estimator that provides the probability of extubation success for an individual preterm infant (http://elasticbeanstalk-us-east-2-676799334712.s3-website.us-east-2.amazonaws.com/).
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