Bacteriological Profile and Antimicrobial Susceptibility Pattern among Isolates Obtained From Body Fluids
Lok Bahadur Shrestha1, Narayan Raj Bhattarai1, Basudha Khanal1
1Department of Microbiology and Infectious Diseases, B. P. Koirala Institute of Health Sciences, Dharan, Sunsari, Nepal.
Journal of Nepal Health Research Council
|August 29, 2019
Summary
Infections in sterile body fluids occur in 10% of cases, with common pathogens like E. coli and S. aureus. Many isolates show multi-drug resistance, necessitating ongoing surveillance for effective treatment.
Area of Science:
- Medical Microbiology
- Infectious Diseases
- Clinical Diagnostics
Background:
- Infections in sterile body sites pose significant clinical urgency and can be life-threatening.
- Early detection and identification of causative organisms are critical for effective patient management.
- This study investigates the prevalence, organism profile, and antimicrobial susceptibility of isolates from sterile body fluid infections.
Purpose of the Study:
- To determine the prevalence of infections in sterile body fluids.
- To identify the common microorganisms causing these infections.
- To analyze the antimicrobial susceptibility patterns of the isolated pathogens.
Main Methods:
- Retrospective analysis of laboratory and clinical records from January 2012 to December 2016.
- Inclusion of all sterile body fluid samples, excluding blood and cerebrospinal fluid.
- Microbiological analysis and antimicrobial susceptibility testing of collected samples.
Main Results:
- An overall isolation rate of 10.68% was observed from 1835 sterile body fluid samples.
- Escherichia coli, Staphylococcus aureus, and Acinetobacter calcoaceticus-baumannii complex were the most frequently identified organisms.
- A significant proportion of isolates exhibited multi-drug resistance (30%) and extensively-drug resistance (10%), with increasing trends observed over the study period.
Conclusions:
- Infections in normally sterile body fluids occur at a rate of approximately 10%.
- Common causative agents include E. coli, S. aureus, and Acinetobacter calcoaceticus-baumannii complex.
- The high prevalence of multi-drug resistant organisms underscores the need for routine surveillance to guide appropriate antimicrobial therapy.
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