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Related Concept Videos

Aggression01:47

Aggression

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Humans engage in aggression when they seek to cause harm or pain to another person. Aggression takes two forms depending on one’s motives: hostile or instrumental. Hostile aggression is motivated by feelings of anger with intent to cause pain; a fight in a bar with a stranger is an example of hostile aggression. In contrast, instrumental aggression is motivated by achieving a goal and does not necessarily involve intent to cause pain (Berkowitz, 1993); a contract killer who murders for...
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Adrenergic Receptors: ɑ Subtype01:31

Adrenergic Receptors: ɑ Subtype

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Adrenoceptors are classified into α and ꞵ classes based on their potencies to catecholamine agonists. α-adrenoceptors show the following order of catecholamine potency:
Adrenaline ≥ Noradrenaline >> Isoprenaline
α-adrenoceptors are further divided into α1 and α2-adrenoceptors.
α1-Adrenoceptors: These receptors are located postsynaptically on the effector organs and cause constriction of smooth muscle mediated by activation of phospholipase...
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Adrenergic Receptors: β Subtype01:26

Adrenergic Receptors: β Subtype

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β-adrenoceptors have varied sensitivities towards adrenaline, noradrenaline, and isoprenaline. The order of agonist potency is as follows:
Isoprenaline > Adrenaline > Noradrenaline
Neurotransmitter binding to these receptors causes activation of adenylyl cyclase resulting in increased concentrations of cAMP and modulation of calcium ion channels within the cell. They are further classified into β1, β2, and β3 subtypes.
β1-adrenoceptors: β1-adrenoceptors...
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Secondary Motives: Affiliation Motivation and Aggression Motivation01:21

Secondary Motives: Affiliation Motivation and Aggression Motivation

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Affiliation motivation is the intrinsic desire to connect with others and belong to a social group, which plays a crucial role in forming and maintaining personal relationships. This type of motivation is essential for psychological well-being, as it provides individuals with a sense of community and support. An example of this is a student who joins a study group in order to feel a sense of connection. People with high affiliation motivation actively seek social approval, take satisfaction in...
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Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

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Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
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Related Experiment Video

Updated: Jan 20, 2026

Initiation of Metastatic Breast Carcinoma by Targeting of the Ductal Epithelium with Adenovirus-Cre: A Novel Transgenic Mouse Model of Breast Cancer
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Initiation of Metastatic Breast Carcinoma by Targeting of the Ductal Epithelium with Adenovirus-Cre: A Novel Transgenic Mouse Model of Breast Cancer

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Targeting CSC in a Most Aggressive Subtype of Breast Cancer TNBC.

Bin Bao1, Ananda S Prasad2

  • 1Department of Oncology, School of Medicine, Wayne State University, Detroit, MI, USA. baob@karmanos.org.

Advances in Experimental Medicine and Biology
|August 29, 2019
PubMed
Summary

Triple negative breast cancer (TNBC) is an aggressive breast cancer subtype. Targeting cancer stem cells (CSCs) offers a promising new therapeutic strategy for TNBC treatment.

Keywords:
Cancer Stem CellsObesity/OverweightTriple Negative Breast Cancer

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Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
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Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model

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Area of Science:

  • Oncology
  • Cancer Biology
  • Molecular Pathology

Background:

  • Triple negative breast cancer (TNBC) is an aggressive subtype lacking common biomarkers, leading to poor prognosis.
  • TNBC is heterogeneous, frequently affects younger women, and is linked to obesity.
  • Current targeted therapies are ineffective due to the absence of standard breast cancer biomarkers.

Purpose of the Study:

  • To explore the role of cancer stem cells (CSCs) in the aggressive behavior of TNBC.
  • To identify potential therapeutic targets within TNBC.
  • To investigate novel treatment strategies for TNBC.

Main Methods:

  • Identification and characterization of CSCs/tumor-initiating cells (TICs) in TNBC tissues.
  • Analysis of CSC/TIC markers and their correlation with TNBC phenotypes.
  • Evaluation of CSC-targeting strategies in preclinical models (details not specified in abstract).

Main Results:

  • CSCs/TICs have been identified within TNBC tumor tissues.
  • These rare cell subpopulations are implicated in TNBC's aggressive traits.
  • CSCs/TICs contribute to drug resistance, metastasis, and tumor recurrence in TNBC.

Conclusions:

  • Cancer stem cells (CSCs) are a significant factor in the aggressive nature of triple negative breast cancer (TNBC).
  • Targeting CSCs presents a novel and potentially effective therapeutic strategy for TNBC.
  • Further research into CSC-specific therapies could improve outcomes for TNBC patients.