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A Novel Model of Mild Traumatic Brain Injury for Juvenile Rats
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A Novel Model of Mild Traumatic Brain Injury for Juvenile Rats

Published on: December 8, 2014

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Proactive inhibition deficits with normal perfusion after pediatric mild traumatic brain injury

Andrew R Mayer1,2,3,4, David D Stephenson1, Christopher J Wertz1

  • 1The Mind Research Network/LBERI, Albuquerque, New Mexico.

Human Brain Mapping
|August 29, 2019
PubMed

Insights

Pediatric mild traumatic brain injury (pmTBI) can cause lasting brain deficits. Our study shows impaired inhibitory control and altered brain activation up to 4 months post-injury in adolescents.

Area of Science:

  • Neuroscience
  • Pediatric Neurology
  • Brain Injury Research

Background:

  • Pediatric mild traumatic brain injury (pmTBI) garners public attention, yet empirical data on biological recovery is limited.
  • Understanding the long-term neural consequences of pmTBI in adolescents is crucial for effective management.

Purpose of the Study:

  • To investigate the natural course of neural recovery following pmTBI in adolescents.
  • To examine functional brain changes during inhibitory control tasks and at rest up to 4 months post-injury.

Main Methods:

  • Prospective cohort study of 50 pmTBI patients (12-18 years) and 53 healthy controls (HC).
  • Functional magnetic resonance imaging (fMRI) during response inhibition and at rest, with cerebral blood flow measurements.
  • High temporal resolution imaging to differentiate neural responses during task preparation and execution.

Main Results:

  • Adolescents with pmTBI showed hyperactivation in motor and sensory areas during inhibitory tasks compared to HC, persisting up to 4 months.
  • Hypoactivation was observed in pmTBI patients within prefrontal cognitive control areas during target processing.
  • Resting-state functional connectivity in motor circuitry was impaired, but resting cerebral perfusion remained normal.

Conclusions:

  • Blood oxygen-level dependent (BOLD) signal deficits during inhibitory control following pmTBI may be more prevalent and persistent than previously thought.
  • Neural recovery from pmTBI in adolescents can extend beyond acute phases, impacting cognitive and motor functions up to 4 months post-injury.

Keywords:
blood oxygen-level dependent responsecerebral blood flowpediatric mild traumatic brain injuryresponse inhibition

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