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Obstetric complications and intelligence in patients on the schizophrenia-bipolar spectrum and healthy participants

Laura Anne Wortinger1,2, Kristine Engen1,2, Claudia Barth2

  • 1Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway.

Psychological Medicine
|August 29, 2019
PubMed

Insights

Severe obstetric complications (OCs) are linked to lower intelligence quotient (IQ) in individuals with schizophrenia (SCZ) and bipolar disorder (BIP). Experiencing multiple OCs significantly impacts cognitive function across psychiatric groups and healthy controls.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Developmental Psychology

Background:

  • Severe obstetric complications (OCs) are known to affect offspring neural development.
  • The contribution of OCs to cognitive impairments in psychiatric disorders remains unclear.

Purpose of the Study:

  • To investigate the association between a history of severe OCs and cognitive functioning, specifically Intelligence Quotient (IQ).

Main Methods:

  • Evaluated 622 healthy controls (HC) and 870 patients with schizophrenia (SCZ) or bipolar disorder (BIP).
  • Assessed premorbid and current IQ using NART and WASI.
  • Obtained OC data from the Medical Birth Registry of Norway and analyzed using multiple linear regression.

Main Results:

  • Severe OCs were equally prevalent across all groups.
  • SCZ patients with OCs showed lower premorbid and current IQ.
  • Multiple OCs were associated with lower current IQ in SCZ, BIP, and HC groups.

Conclusions:

  • Severe OCs are linked to reduced IQ in SCZ and, with multiple complications, in BIP and HC groups.
  • OCs may represent a neurodevelopmental risk factor for SCZ, influencing cognitive abilities.
  • Considering OCs in neurodevelopmental risk assessment can inform interventions and improve clinical prognoses.
Abstract

Keywords:
Bipolar spectrumcognitionintelligencemood disorders bipolarneuropsychologyobstetric complicationsobstetric gynecologypremorbid IQschizophreniaschizophrenia spectrum

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