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Catalytic Knockdown of miR-21 by Artificial Ribonuclease: Biological Performance in Tumor Model

Olga A Patutina1, Svetlana K Miroshnichenko1, Nadezhda L Mironova1

  • 1Laboratory of Nucleic Acids Biochemistry, Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia.

Frontiers in Pharmacology
|August 29, 2019
PubMed
Summary

We developed a catalytic RNA-cleaving enzyme (miRNase) that effectively targets and degrades oncogenic microRNAs (miRNAs). This novel approach offers persistent suppression of tumor cell growth and invasiveness.

Keywords:
RNA cleavageRNase Hanti-miRNA therapyartificial ribonucleasemiRNA-21oligonucleotide-peptide conjugate

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