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Do Changes in Oral Microbiota Correlate With Plasma Nitrite Response? A Systematic Review
Khrystyna Zhurakivska1, Giuseppe Troiano1, Vito Carlo Alberto Caponio1
1Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
Frontiers in Physiology
|August 29, 2019
Summary
Antibacterial mouthwash use may reduce plasma nitrite levels, impacting nitric oxide (NO) regulation. Further research is needed to confirm the link between oral bacteria, NO, and overall health.
Area of Science:
- Microbiology
- Physiology
- Nutrition
Background:
- Nitric Oxide (NO) is vital for immune defense, blood flow, and mitochondrial function.
- Dietary nitrate (NO3-) and endogenous L-arginine are sources of NO.
- Oral and intestinal bacteria metabolize nitrate to nitric oxide (NO).
Conclusions:
- Oral bacteria play a role in salivary nitrate metabolism, but their effect on plasma NO species is unclear.
- Current evidence on oral microbiota's influence on plasma NO is ambiguous.
- Larger studies are required to confirm the impact of oral microbiota on nitrate/nitrite/NO levels and associated biological processes.
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