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Safety and Efficacy of Pneumococcal Vaccination in Pediatric Nephrotic Syndrome

Shamitha Thishakya Goonewardene1,2,3, Calyn Tang1,2,3, Loh Teng-Hern Tan2,4

  • 1Medical Health and Translational Research Group, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Subang Jaya, Malaysia.

Frontiers in Pediatrics
|August 29, 2019
PubMed

Insights

Nephrotic syndrome patients face high pneumococcal infection risks. This review examines pneumococcal vaccine effectiveness and safety in these vulnerable individuals, crucial for guiding treatment strategies.

Area of Science:

  • Pediatric Nephrology
  • Infectious Disease Immunology
  • Vaccinology

Background:

  • Nephrotic syndrome increases susceptibility to severe pneumococcal infections.
  • Immunosuppressive therapy and immune deficiency in nephrotic syndrome exacerbate infection risks.
  • Rising antibiotic resistance necessitates effective preventative measures like vaccination.

Purpose of the Study:

  • To review evidence on pneumococcal vaccine immunogenicity and safety in nephrotic patients.
  • To assess the impact of nephrotic syndrome treatment on vaccine responses.
  • To inform vaccination guidelines for children with nephrotic syndrome.

Main Methods:

  • Systematic review of existing literature on pneumococcal vaccination in nephrotic syndrome.
  • Analysis of studies evaluating polysaccharide and conjugated pneumococcal vaccines.
  • Examination of data on vaccine seroresponse and adverse events.

Main Results:

  • Limited data currently exists on optimal pneumococcal vaccination strategies for nephrotic children.
  • Evidence on vaccine immunogenicity and safety in this population requires further investigation.
  • Treatment for nephrotic syndrome may influence vaccine efficacy.

Conclusions:

  • Pneumococcal vaccination is critical for nephrotic children due to high infection risk.
  • More research is needed to establish definitive guidelines for vaccine use in this cohort.
  • Understanding treatment effects on seroresponse is essential for optimizing protection.

Keywords:
efficacynephroticpediatricpneumococcalvaccination

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