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Bone histomorphometry, bone mass, and related parameters in alcoholic males
R G Crilly1, C Anderson, D Hogan
1Department of Medicine and Pathology, University of Western Ontario, London, Canada.
Calcified Tissue International
|November 1, 1988
Summary
Regular alcohol abuse negatively impacts bone formation, particularly in heavy drinkers, leading to reduced bone density and increased fracture risk. Biochemical markers like alkaline phosphatase and hydroxyproline may indicate bone issues.
Area of Science:
- Bone Metabolism
- Alcohol-Induced Osteoporosis
- Skeletal Health
Background:
- Alcohol abuse is a significant risk factor for bone loss and fractures.
- The specific effects of alcohol on bone formation and resorption parameters require further elucidation.
Purpose of the Study:
- To investigate the impact of alcohol consumption on bone mass, metabolic variables, and bone histomorphometry in male alcohol abusers.
- To differentiate the effects of alcohol on bone formation versus resorption.
Main Methods:
- Study included 50 male alcohol abusers, divided into current drinkers (moderate/heavy) and abstainers (≥3 months).
- Bone mineral density (BMD), iliac crest bone volume, and histomorphometry were assessed.
- Biochemical markers (alkaline phosphatase, hydroxyproline) and hormonal levels (PTH, testosterone, cortisol) were measured.
Main Results:
- Spinal crush fracture cases showed lower lumbar BMD and iliac crest bone volume.
- Alcohol drinkers exhibited reduced bone formation (lower osteoid seam width, fewer osteoblasts) and prolonged mineralization lag time.
- Heavy drinkers, not moderate, showed reduced lacunae surface extent, suggesting impaired resorption.
- Alkaline phosphatase and hydroxyproline were elevated in osteoporotic individuals.
Conclusions:
- Alcohol consumption detrimentally affects bone formation more than resorption.
- Histomorphometric differences were observed between drinkers and abstainers, indicating impaired bone remodeling due to alcohol.
- Biochemical markers like alkaline phosphatase and hydroxyproline excretion may indicate alcohol-related bone disease.