Readily Available Highly Active [Ti]-Adamantyl-BINOL Catalysts for the Enantioselective Alkylation of Aldehydes
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Updated: Jan 20, 2026

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
Published on: January 17, 2020
Rodrigo Navarro1, Cristina Monterde1,2, Marta Iglesias2
1Instituto de Química Orgánica (CSIC), Madrid 28006, Spain.
Abstract:
A series of enantiopure (R)-adamantyl 1,1'-binaphthalene-2,2'-diols were successfully synthesized in a straightforward one-step reaction from commercial products with excellent overall yields. The activity of chiral titanium catalyst derived from (R)-3,6,6'-tri(adamantan-1-yl)-[1,1'-binaphthalene]-2,2'-diol ligand, (, in the enantioselective asymmetric alkylation of aldehydes is significantly enhanced (up to 98% yield and 99% ee).
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