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Updated: Jan 20, 2026
Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
Published on: November 30, 2022
Diastereoselective Synthesis of (±)-epi-Subincanadine C
Manojkumar G Kalshetti1,2, Narshinha P Argade1,2
1Division of Organic Chemistry, National Chemical Laboratory (CSIR), Pune 411008, India.
Abstract:
Starting from indolylmaleimide, concise and efficient total synthesis of (±)-epi-subincanadine C was described via stereoselective Wittig olefination, base-induced selective mono-prenylation, regioselective Grignard reaction, diastereoselective Pictet-Spengler cyclization, regioselective oxidative carbon-carbon double-bond cleavage, one-pot reductions, and intramolecular cyclization pathway. An attempted synthesis of (±)-subincanadine C via diastereoselective Grignard addition to the α,β-unsaturated γ-lactam or diastereoselective reduction of a carbon-carbon double bond also resulted in yet another route to (±)-epi-subincanadine C.
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