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Updated: Jan 20, 2026
Gold Nanoparticle Synthesis
Published on: July 10, 2021
Efficient Gold(I) Acyclic Diaminocarbenes for the Synthesis of Propargylamines and Indolizines
Mélanie Aliaga-Lavrijsen1, Raquel P Herrera1, M Dolores Villacampa1
1Departamento de Química Inorgánica, Instituto de Síntesis Química y Catálisis Homogénea (ISQCH), and Departamento de Química Orgánica, Laboratorio de Organocatálisis Asimétrica, Instituto de Síntesis Química y Catálisis Homogénea (ISQCH), CSIC-Universidad de Zaragoza, C/ Pedro Cerbuna, No. 12, E-50009 Zaragoza, Spain.
Abstract:
Mononuclear gold(I) acyclic diaminocarbenes (ADCs) were prepared by the reaction of 1,2-cyclohexanediamine with the corresponding isocyanide complexes [AuCl(CNR)] (R = Cy, Bu). The three-component coupling of aldehydes, amines, and alkynes was investigated by using these gold(I) ADC complexes. The new gold(I) metal complexes are highly efficient catalysts for the synthesis of propargylamines and indolizines in the absence of solvent and in mild conditions. This method affords the corresponding final products with excellent yields in short reaction times. Additionally, chiral gold(I) complexes with ADCs have been prepared and tried in the enantioselective synthesis of propargylamines.
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