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Updated: Jan 20, 2026
Absolute Quantitation of Inositol Pyrophosphates by Capillary Electrophoresis Electrospray Ionization Mass Spectrometry
Published on: August 13, 2021
Development and Evaluation of Polyether Ether Ketone (PEEK) Capillary for Electrospray
Christian Sögaard1, Isabelle Simonsson1, Zareen Abbas1
1Department of Chemistry and Molecular Biology, University of Gothenburg, Kemivägen 10, 41296 Gothenburg, Sweden.
A new polyether ether ketone (PEEK) capillary for electrospray scanning mobility particle sizer (ES-SMPS) analysis allows accurate nanoparticle size distribution measurement for both positive and negative charged particles, overcoming limitations of silica capillaries.
Area of Science:
- Nanotechnology
- Colloidal Science
- Analytical Chemistry
Background:
- Accurate nanoparticle characterization is crucial in nanotechnology.
- Dynamic light scattering can be influenced by aggregates.
- Electrospray scanning mobility particle sizer (ES-SMPS) is a promising technique for particle size distribution analysis.
- Silica capillaries in ES-SMPS are negatively charged, limiting analysis of positively charged nanoparticles.
Purpose of the Study:
- To develop a new capillary material for ES-SMPS to overcome limitations with charged nanoparticles.
- To enable precise particle size distribution determination for both positively and negatively charged colloidal sols.
Main Methods:
- Development of a polyether ether ketone (PEEK) capillary for ES-SMPS.
- Testing the PEEK capillary with negatively charged nanoparticles (SiO2, Au, latex).
- Testing the PEEK capillary with positively charged nanoparticles (TiO2).
- Comparison of ES-SMPS results using PEEK vs. silica capillaries.
Main Results:
- PEEK capillaries provide particle size distributions comparable to silica capillaries for negatively charged particles.
- PEEK capillaries enable precise particle size distribution measurements for positively charged nanoparticles.
- PEEK capillaries are a cost-effective alternative to silica capillaries.
Conclusions:
- The PEEK capillary effectively removes the charge limitation of silica capillaries in ES-SMPS.
- ES-SMPS with PEEK capillaries is a versatile and cost-effective method for characterizing colloidal sols.
- This advancement broadens the applicability of ES-SMPS in colloidal science and nanotechnology.
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