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Updated: Jan 20, 2026
Solid Phase Synthesis: Principles, Peptide Synthesis
Published on: April 30, 2023
Green Process without Thinning Agents for Preparing Sebacic Acid via Solid-Phase Cleavage
Siyuan Yu1, Jianlan Cui1, Congshan Zhong1
1School of Chemical Engineering and Technology and Software School, North University of China, Taiyuan 030051, Shanxi, China.
Abstract:
A green and environmentally friendly route of no thinning agent was designed to prepare sebacic acid. Sodium ricinoleate was selected as the raw material to carry out solid-phase cleavage in a tubular furnace. The reaction parameters including catalyst, ratio of sodium ricinoleate/KOH, reaction time, reaction temperature, and absolute pressure were optimized to obtain a high yield of sebacic acid. A satisfactory yield (70.2%) of sebacic acid was received in the presence of 1% catalyst (Fe2O3) by weight (w/w), with 5:4 (w/w) ratio of sodium ricinoleate/KOH at 543 K under the absolute pressure of 0.09 MPa in 60 min. Sebacic acid was identified by gas chromatography analysis, and the purity (98.1%) of the product was further assessed by its melting point (306.3 K). Alkaline enhancement generates a better cracking effect. The yield of sebacic acid can be improved by a certain absolute pressure as a result of avoiding oxidation of sodium ricinoleate as well as reducing the residence time of hydrogen.
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