Carbon Quantum Dot-Modified Carbon Paste Electrode-Based Sensor for Selective and Sensitive Determination of...

Area of Science:

• Electrochemistry
• Nanomaterials Science
• Analytical Chemistry

Background:

• Adrenaline (AD) determination is crucial for clinical diagnostics and pharmaceutical quality control.
• Existing methods for AD detection often suffer from limited sensitivity, selectivity, or complex procedures.
• Carbon quantum dots (CQDs) offer unique electrochemical properties for sensor development.

Purpose of the Study:

• To fabricate a CQD-based carbon paste electrode for sensitive and selective adrenaline detection.
• To investigate the electrochemical behavior and performance of the modified electrode for AD oxidation.
• To evaluate the electrode's ability for simultaneous determination of AD with interfering biomolecules and its application in real samples.

Main Methods:

• Fabrication of a carbon paste electrode modified with carbon quantum dots.
• Electrochemical characterization using cyclic voltammetry and chronoamperometry.
• Investigation of electrocatalytic activity towards adrenaline oxidation.
• Assessment of selectivity against ascorbic acid (AA) and serotonin (5-HT).
• Real-time analysis using adrenaline bitartrate injections.

Main Results:

• The CQD-modified electrode exhibited excellent electrocatalytic activity for adrenaline oxidation.
• A low detection limit of 6 nM for AD was achieved.
• The modified electrode demonstrated high selectivity for AD in the presence of AA and 5-HT.
• Simultaneous determination of AA, AD, and 5-HT was successfully achieved with well-resolved peaks.
• The electrode showed good stability, antifouling properties, and applicability to real pharmaceutical samples.

Conclusions:

• The CQD-based carbon paste electrode provides a sensitive, selective, and stable platform for adrenaline detection.
• This method offers a promising approach for the accurate quantification of adrenaline in complex biological and pharmaceutical matrices.
• The developed electrode facilitates simultaneous analysis of key biomolecules, enhancing diagnostic and analytical capabilities.